Age-related changes to lymph node microarchitecture and impacts on T cell responses

与年龄相关的淋巴结微结构变化及其对 T 细胞反应的影响

• 批准号: 466763
• 负责人: Bhagrath Aanya
• 金额: $ 1.27万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466763&lang=en
• 关键词: Dna Damage; Fibroblastic Reticular Cells; Immunosenescence; Lymph Nodes; Machine Learning Algorithms; Mechanical Stiffness; Nuclear Envelope; Quantitative Imaging; Stromal Cells; T Cells

The COVID-19 pandemic has illustrated that elderly people are at much higher risk of developing severe symptoms from infection. This is partly due to reduced responsiveness of T cells, a type of immune cell that protects the body from foreign invaders, su

COVID-19疫情表明，老年人因感染而出现严重症状的风险要高得多。这部分是由于T细胞的反应性降低，T细胞是一种保护身体免受外来入侵者侵害的免疫细胞，