Modular synthesis of nucleic acid radiopharmaceuticals for positron emission tomography

正电子发射断层扫描核酸放射性药物的模块化合成

• 批准号: 466634
• 负责人: Wong Wai Long Antonio
• 金额: $ 1.27万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466634&lang=en
• 关键词: Antibody-Oligonucleotide Conjugates; Antisense Recognition; Chemical Biology; Modified Nucleotides; Nucleic Acid Chemistry; Positron Emission Tomography (Pet); Pre-Targeting; Radioimmunotherapy; Tumor Localization

Monoclonal antibodies (mAbs) have revolutionized cancer therapy, and trastuzumab has revolutionized HER2+ breast cancer. Increasingly, antibody drug conjugates such as trastuzumab emtansine play an important role in the treatment of relapsed disease. Posi

单抗使癌症治疗发生了革命性变化，曲妥珠单抗使HER2+乳腺癌发生了革命性变化。越来越多的抗体药物结合物，如曲妥珠单抗，在治疗复发疾病中发挥着重要作用。位置