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Single-cell transcriptional and epigenetic profiling of regenerative decline in reindeer ectopic skin grafts.

Single-cell transcriptional and epigenetic profiling of regenerative decline in reindeer ectopic skin grafts.
驯鹿异位皮肤移植再生衰退的单细胞转录和表观遗传分析。
批准号：
466504
负责人：
Jaffer Arzina
金额：
$1.27万
依托单位：
University of Calgary
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2021
资助国家：
加拿大
项目状态：
已结题
起止时间：
2021-12-01 至 2022-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466504&lang=en
关键词：
Bioinformatics Ectopic Grafting Genomics Single-Cell Sequencing Skin Fibroblasts Skin Grafting Stem Cell Biology Tissue Fibrosis Tissue Regeneration Wound Healing

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Mammalian evolution has selected for rapid tissue repair, rather than regeneration, in order to prioritize survival. Although effective in preventing infection, the consequence of such hastened repair is formation of fibrotic scar that leads to impaired t
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