Investigating the role of the retinoblastoma protein in regulating heterochromatin and maintaining genome stability

研究视网膜母细胞瘤蛋白在调节异染色质和维持基因组稳定性中的作用

• 批准号: 206099
• 负责人: Coschi Courtney H
• 金额: $ 5.1万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-10-01 至 2011-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=206099&lang=en
• 关键词: Cancer; Cell Division Cycle Regulation; Centromere; Chromosome Architecture; Condensin; Genomic Instability; Live Cell Video Microscopy; Mouse Model; Regulation Of Heterochromatin; Retinoblastoma Protein

The retinoblastoma (pRb) protein is a tumor suppressor, which plays a role in cell division cycle control by preventing abnormal cell growth, and deregulation of pRb is frequently found in cancer. Recently, pRb has been proposed to have an important inte

视网膜母细胞瘤 (pRb) 蛋白是一种肿瘤抑制因子，通过防止异常细胞生长在细胞分裂周期控制中发挥作用，pRb 失调在癌症中常见。 最近，pRb 被认为具有重要的作用。