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Identification and targeting of metabolic dependencies in high-risk AML

高风险 AML 代谢依赖性的识别和靶向

批准号：

466895

负责人：

Partrick Owen W

金额：

$1.27万

依托单位：

University of British Columbia

依托单位国家：

加拿大

项目类别：

Studentship Programs

财政年份：

2021

资助国家：

加拿大

项目状态：

已结题

起止时间：

2021-12-01 至 2022-12-01

来源：

https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466895&lang=en

关键词：

Acute Myeloid Leukemia Chemotherapy Electron Transport Chain Energy Metabolism Modulation Inv(3)/T(3 3) Leukemic Stem Cells Mecom Mitochondria Oxphos Inhibitors Targeted Therapy

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英文摘要

Acute Myeloid Leukemia (AML) is a heterogenous disease, with a diversity of genetic subgroups and outcomes. Bleak outcomes are common for certain subtypes due to lack of response to therapy, high relapse rates, as well as a lack of targeted therapies. One

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