Post translational modification of type IV collagen compensates for basement membrane abnormalities in the kidney glomerulus

IV 型胶原的翻译后修饰可补偿肾小球基底膜异常

• 批准号: 467100
• 负责人: De Gregorio Vanessa S
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=467100&lang=en
• 关键词: Alport Syndrome; Developmental Genetics; Drug Development; Post-Translational Modifications; Protein Dysregulation; Type Iv Collagen

Chronic kidney disease is a major global health concern, affecting 850M individuals and resulting in 1M deaths per year. The commonest monogenic disorder that affects the kidneys filtration function is Alport syndrome (AS), leading to multisystem disease

慢性肾脏疾病是一个主要的全球健康问题，影响8.5亿人，每年导致100万人死亡。最常见的影响肾脏滤过功能的单基因疾病是Alport综合征（AS），可导致多系统疾病