Linking choline metabolism to macrophage metabolic reprogramming

将胆碱代谢与巨噬细胞代谢重编程联系起来

• 批准号: 467061
• 负责人: Ilijevska Maja
• 金额: $ 1.27万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=467061&lang=en
• 关键词: Choline; Macrophage; Metabolism; Pro-Inflammatory

Choline is an essential nutrient that provides a critical precursor for membrane phospholipids, the neurotransmitter acetylcholine, and methyl groups for epigenetic regulation. In innate immune cells called macrophages, choline is needed for lipid homeost

胆碱是一种必需的营养素，为膜磷脂、神经递质乙酰胆碱和表观遗传调节的甲基提供关键前体。在称为巨噬细胞的先天免疫细胞中，胆碱是脂质平衡所必需的。