Regulation of LRIG1 and its functional role following brain injury.

脑损伤后 LRIG1 的调节及其功能作用。

• 批准号: 466731
• 负责人: Ouzikov Stephanie
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466731&lang=en
• 关键词: Brain Injury; Cell Signalling Inhibition; Cellular Differentiation; Central Nervous System; Gene Expression; Gene Targeting; Leucine-Rich Repeats And Immunoglobulin-Like Domains 1; Neural Stem Cells; Neurogenesis; Stroke

Neural stem cells (NSCs) are largely quiescent in nature and divide infrequently for brain maintenance and during times of brain injury. However, even after stroke injury, these newborn neurons migrate to the lesion site, of which most NSC die. LRIG1 is a

神经干细胞（NSC）在本质上基本上是静止的，并且在脑损伤期间很少分裂用于脑维护。然而，即使在中风损伤后，这些新生神经元迁移到病变部位，其中大多数NSC死亡。LRIG1是一个