Plant Biotechnology

植物生物技术

• 批准号: CRC-2015-00294
• 负责人: DeLuca, Vincenzo
• 金额: $ 14.57万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=729676
• 关键词: Plant; Biotechnology

The increasing demands of a growing human population for energy, food, building materials, agricultural inputs and medicine is placing important strains on the ability of the natural world to accommodate these pressing needs. Our research will increase our knowledge about the mechanisms that plants use for producing and accumulating medicinally important secondary metabolites. These studies utilize the Madagascar periwinkle (Catharanthus roseus) as a model system to examine how this beautiful plant makes the remarkably complex alkaloids that have saved many human beings from devastating cancers. The knowledge allows pathways to be transferred to micro-organisms where large amounts of these anticancer agents can be produced for human use.

日益增长的人口对能源、粮食、建筑材料、农业投入和医药的需求日益增加，对自然界满足这些迫切需求的能力造成了重大压力。 我们的研究将增加我们对植物用于生产和积累药用重要的次级代谢产物的机制的了解。这些研究利用马达加斯加长春花（Catharanthus roseus）作为模型系统，研究这种美丽的植物是如何产生非常复杂的生物碱的，这些生物碱拯救了许多人类免于毁灭性的癌症。这些知识允许将途径转移到微生物中，在微生物中可以生产大量的这些抗癌剂供人类使用。