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A phase 2 study of mirdametinib and vinblastine for newly diagnosed or previously untreated patients with pediatric low-grade glioma and activation of the MAPK pathway

A phase 2 study of mirdametinib and vinblastine for newly diagnosed or previously untreated patients with pediatric low-grade glioma and activation of the MAPK pathway
Mirdametinib 和长春花碱治疗新诊断或既往未经治疗的儿童低级别胶质瘤患者和 MAPK 通路激活的 2 期研究
批准号:
465505
负责人:
Perreault Sebastien
金额:
$33.77万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2022
资助国家:
加拿大
项目状态:
已结题
起止时间:
2022-03-01 至 2023-08-01
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英文摘要
Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. Whereas, some patients can be cured with surgery alone, a significant number will need complimentary treatments since location such as optic pathway or brainstem precludes
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A Phase 2 study of Trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathwa
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