Hyperactive mitochondria: a novel mechanism to explain early life stress-related sleep apneas in adult mice

线粒体过度活跃：解释成年小鼠早期生活压力相关睡眠呼吸暂停的新机制

• 批准号: 461071
• 负责人: Soliz Jorge
• 金额: $ 51.27万
• 依托单位: Institut universitaire de cardiologie et de pneumologie de Qubec - U Laval
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-03-01 至 2027-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=461071&lang=en
• 关键词: Brainstem; Breathing Dysfunction; Gaba; Hypothalamo-Pituitary-Adrenal Axis; Mitochondria; Neonatal Tress; Nucleus Tractus Solitarii (Nts); Paraventricular Nucleus Of The Hypothalamus (Pvh); Sex Dimorphism; Sleep Apnea

Mitochondria are small organelles within cells that generate almost all the energy we need throughout life. The human brain, being the most energy-demanding organ, consumes between 50% (in postnatal age) and 20% (in adulthood) of this energy. In fact, the

线粒体是细胞内的小细胞器，几乎可以产生我们一生所需的所有能量。人类大脑是最需要能量的器官，消耗50%（出生后）到20%（成年）的能量。实际上