Generation of Non-Immunogenic Human Tracheal Grafts for Transplantation

用于移植的非免疫原性人气管移植物的生成

• 批准号: 461948
• 负责人: Karoubi Golnaz
• 金额: $ 55.17万
• 依托单位: University Health Network (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-03-01 至 2027-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=461948&lang=en
• 关键词: Airway Patches; Airway Regeneration; Biological Scaffolds; Cell Therapy; Designer Cells; Epithelial Cells; Human Induced Pluripotent Stem Cells; Immunology; Trachea; Transplantation

Cancer, trauma and narrowing of long segments of the airway are very difficult to reconstruct and require novel solutions. Attempts at transplantation of donor airway and tissue engineered constructs have faced two major challenges: (1) inability to produ

癌症、创伤和长段气道狭窄非常难以重建，需要新的解决方案。移植供者气道和组织工程构建物的尝试面临两个主要挑战：（1）不能产生足够的细胞，