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Role of the RAS Pathway Activation on the Biology and Drug Response of Acute Myeloid Leukemias

Role of the RAS Pathway Activation on the Biology and Drug Response of Acute Myeloid Leukemias
RAS 通路激活对急性髓系白血病生物学和药物反应的作用
批准号：
468616
负责人：
Barab Frdric
金额：
$64.93万
依托单位：
Universit Laval
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-09-01 至 2027-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=468616&lang=en
关键词：
Clonal Evolution Crispr Induced Gene Mutation Engineered Human Leukemia Models Gene Expression Profiles Human Acute Leukemias Kmt2a Fusion Gene Leukemic Stem Cell Frequency Ras Pathway Small Molecule High-Throughput Screen Xenograft Models

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Despite advances in the treatment of acute leukemias over the past 20 years, they are still a leading cause of death by cancer before the age of 40. Also, their incidence grows exponentially after 60 years old and the overall survival 2 years after diagno
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Biology of S100A8 and S100A9 proteins in Human Acute Myeloid Leukemia
  • 批准号：
    400666
  • 项目类别：
    Operating Grants
  • 资助金额：
    $55.45万
  • 财政年份：
    2019
  • 负责人：
    Barab Frdric
  • 依托单位：
    Universit Laval