The role of microgliosis in cerebellar underdevelopment of prematurity

小胶质细胞增生在早产儿小脑发育不全中的作用

• 批准号: 469386
• 负责人: Tremblay Sophie
• 金额: $ 57.4万
• 依托单位: Centre hospitalier universitaire Sainte-Justine (Montral, Qubec)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-09-01 至 2027-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=469386&lang=en
• 关键词: Cerebellar Haemorrhage; Cerebellar Underdevelopment; Electrophysiology; Excitatory/Inhibitory Balance; Inflammation; Microglia; Perinatal Insults; Prematurity; Purkinje Cells; Translational Animal Model

Despite a dramatic improvement in survival of infants born very preterm and a major decrease in severe brain injury, almost half of these infants will still suffer from long-term functional problems. The cerebellum is highly vulnerable during the second h

尽管早产儿的存活率有了显著提高，严重脑损伤的发生率也大大降低，但这些婴儿中仍有近一半会出现长期的功能问题。小脑在第二个小时非常脆弱