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Tissue Engineering of 3D bone marrow niche for hematopoietic stem cells vs acute myeloid leukemia stem cell molecular target and therapeutics discovery

Tissue Engineering of 3D bone marrow niche for hematopoietic stem cells vs acute myeloid leukemia stem cell molecular target and therapeutics discovery
造血干细胞 3D 骨髓生态位的组织工程与急性髓系白血病干细胞分子靶标和治疗发现
批准号：
468535
负责人：
Sachlos Eleftherios
金额：
$53.22万
依托单位：
York University (Toronto, Ontario)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-09-01 至 2027-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=468535&lang=en
关键词：
3d Extracellular Matrix Acute Myeloid Leukemia - Leukemic Stem Cells Drug Discovery Hematopoietic Stem Cells In Vitro Myelosuppression Assay Liquid Biopsy Personalized Cancer Medicine Screening Stem Cell Niche Tissue Engineering

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Mounting scientific evidence suggests that a unique population of leukemic stem cells (LSC) are responsible for driving acute myeloid leukemia growth and resistance to drug treatment. However extracting these LSC from patients and growing them under labo
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