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Targeting defective cells to restore myogenesis and muscle function in myotonic dystrophy type 1

Targeting defective cells to restore myogenesis and muscle function in myotonic dystrophy type 1
靶向缺陷细胞以恢复 1 型强直性肌营养不良症的肌生成和肌肉功能
批准号：
468466
负责人：
Dumont Nicolas
金额：
$55.45万
依托单位：
Centre hospitalier universitaire Sainte-Justine (Montral, Qubec)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-09-01 至 2027-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=468466&lang=en
关键词：
Extracellular Matrix Fibro-Adipogenic Progenitors Inflammation Mesenchymal Stem Cells Muscle Stem Cell Muscular Dystrophies Myotonic Dystrophy Type 1 Regeneration Senescence Skeletal Muscle

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中文摘要
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英文摘要
Myotonic dystrophy type 1 (DM1) is the most frequent genetic muscle diseases in adults. The disease affects different organs, especially skeletal muscle, leading to progressive muscle weakness and physical incapacities. Moreover, it was shown that the mus
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