Development of distributed wireless implantable sensors for the management of heart failure (HF)

开发用于治疗心力衰竭(HF)的分布式无线植入传感器

基本信息

  • 批准号:
    RGPIN-2021-03151
  • 负责人:
  • 金额:
    $ 2.04万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2021
  • 资助国家:
    加拿大
  • 起止时间:
    2021-01-01 至 2022-12-31
  • 项目状态:
    已结题

项目摘要

Heart failure affects more than 600,000 Canadians and 26 million people worldwide. The direct economic impact of heart failure is estimated to be $2.8 billion per year in Canada, with a significant portion of this cost associated to hospitalizations and emergency room visits. Beside frequent hospitalizations, HF patients must undergo uncomfortable diagnostic procedures and physical examinations. Remote monitoring (or telemonitoring) was introduced in the 1990's to detect the worsening of a patient's condition at a home setting before the need for emergency hospitalization. At the time, remote monitoring relied on patients to record their physiological parameters, such as weight and blood pressure, and communicate them to their clinical team over the phone. The need for more effective methods of remote monitoring led medical companies to incorporate sensors in traditional implantable pacemaker and cardioverter devices. These sensors are capable of real-time monitoring of several parameters, including electrical activity, blood pressure and fluid levels in the lungs, which are directly related to potential heart failure. While these devices no longer required patients' active participation and compliance, they did involve additional surgical procedure leading to potential risks and complications. To eliminate the need to implant long extension cables, insertable wireless monitors have recently been developed. Sized like paperclips, these monitors can be inserted through small incisions or simple catheter procedures. In the context of heart failure, the most successful clinical device is a pressure sensor implanted in the pulmonary artery. While this device is currently widely adopted as an early indicator of worsening of heart failure, the system requires patients to operate an external electronic unit daily. Moreover, current wireless monitors are designed to measure one parameter from one specific anatomical area. The true ambition of cardiac research is to measure several relevant parameters concurrently from different anatomical regions using non-invasive or minimally invasive tools. To fulfill this goal, this program proposes the development of a smart network of miniaturized wireless biosensing modules for remote monitoring of heart failure. By distributing these sensors across relevant anatomical regions, accurate measurement of physical, electrical and chemical parameters will be possible without the need for expensive and uncomfortable procedures. Leveraging semiconductor technology, the biosensing devices will be miniaturized to the scale of a grain of rice without sacrificing performance. A central implant unit will be responsible of collecting data and controlling sensor activity. Combined multi-parameter data will provide rich information about the patients' status in real-time and will ensure timely monitoring and management of heart failure.
心力衰竭影响着60多万加拿大人和全世界2600万人。在加拿大,心力衰竭的直接经济影响估计为每年28亿美元,其中很大一部分与住院和急诊室就诊有关。除了频繁住院外,心衰患者还必须接受不舒服的诊断程序和体格检查。远程监测(或远程监测)是在20世纪90年代引入的,目的是在需要紧急住院治疗之前,在家庭环境中发现患者病情的恶化。当时,远程监控依赖于患者记录他们的生理参数,如体重和血压,并通过电话与他们的临床团队沟通。由于需要更有效的远程监测方法,医疗公司将传感器集成到传统的植入式起搏器和心律转复器设备中。这些传感器能够实时监测几个参数,包括电活动、血压和肺部体液水平,这些参数与潜在的心力衰竭直接相关。虽然这些设备不再需要患者积极参与和遵守,但它们确实涉及额外的外科手术,导致潜在的风险和并发症。为了消除植入长延长线的需要,最近开发了可插入式无线监视器。这些监测仪像回形针一样大小,可以通过小切口或简单的导管程序插入。在心力衰竭的情况下,最成功的临床装置是植入肺动脉的压力传感器。虽然该设备目前被广泛采用作为心力衰竭恶化的早期指标,但该系统需要患者每天操作外部电子装置。此外,目前的无线监测器被设计为测量一个特定解剖区域的一个参数。心脏研究的真正目标是使用无创或微创工具同时测量不同解剖区域的几个相关参数。为了实现这一目标,本计划提出开发一个微型无线生物传感模块的智能网络,用于远程监测心力衰竭。通过将这些传感器分布在相关的解剖区域,可以在不需要昂贵和不舒服的程序的情况下精确测量物理、电气和化学参数。利用半导体技术,在不牺牲性能的情况下,将生物传感装置缩小到一粒米的大小。一个中央植入装置将负责收集数据和控制传感器活动。综合多参数数据将提供丰富的患者实时状态信息,确保心衰的及时监测和管理。

项目成果

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Valente, Virgilio其他文献

Practical Inductive Link Design for Biomedical Wireless Power Transfer: A Tutorial
An Implantable Stimulator With Safety Sensors in Standard CMOS Process for Active Books
  • DOI:
    10.1109/jsen.2016.2577688
  • 发表时间:
    2016-10-01
  • 期刊:
  • 影响因子:
    4.3
  • 作者:
    Liu, Xiao;Valente, Virgilio;Demosthenous, Andreas
  • 通讯作者:
    Demosthenous, Andreas

Valente, Virgilio的其他文献

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{{ truncateString('Valente, Virgilio', 18)}}的其他基金

Development of distributed wireless implantable sensors for the management of heart failure (HF)
开发用于治疗心力衰竭(HF)的分布式无线植入传感器
  • 批准号:
    RGPIN-2021-03151
  • 财政年份:
    2022
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Grants Program - Individual
Development of distributed wireless implantable sensors for the management of heart failure (HF)
开发用于治疗心力衰竭(HF)的分布式无线植入传感器
  • 批准号:
    DGECR-2021-00267
  • 财政年份:
    2021
  • 资助金额:
    $ 2.04万
  • 项目类别:
    Discovery Launch Supplement

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