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Viralyzing transgenes to improve oncolytic immunotherapy

Viralyzing transgenes to improve oncolytic immunotherapy
病毒裂解转基因以改善溶瘤免疫疗法
批准号：
472390
负责人：
Alain Tommy
金额：
$7.29万
依托单位：
Children's Hospital of Eastern Ontario Research Institute Inc
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
已结题
起止时间：
2022-09-01 至 2023-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=472390&lang=en
关键词：
5'Leader Sequences Cancer Cells Codon Optimization Herpes Simplex Virus Immunotherapy Mrna Stability Mrna Translation Promoter Regions Transgene Expression Vaccinia Virus

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中文摘要
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英文摘要
Cancer killing viruses carry a "payload" as a form of a "transgene". This payload is critical for their anti-cancer efficacy. The transgene is often a carbon copy of a human gene, but we know that the human genetics is very different to that of a virus. T
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Viralyzing transgenes to improve oncolytic immunotherapy.
Oral Administration of Reoviruses for the Treatment, Prevention and Early Diagnosis of Colorectal Cancer.
Characterization of a new pharmao-viral approach for the treatment of brain cancer
  • 批准号：
    372713
  • 项目类别：
    Operating Grants
  • 资助金额：
    $4.37万
  • 财政年份：
    2017
  • 负责人：
    Alain Tommy
  • 依托单位：
    University of Ottawa
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