Are changes in skeletal muscle mitochondrial respiratory capacity responsible for lactate release and loss of vascular regulation in sepsis and COVID-19?
Are changes in skeletal muscle mitochondrial respiratory capacity responsible for lactate release and loss of vascular regulation in sepsis and COVID-19?
骨骼肌线粒体呼吸能力的变化是否导致脓毒症和 COVID-19 中乳酸释放和血管调节丧失？
批准号：
472002
负责人：
Caldwell Hannah G
金额：
$10.93万
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-10-01 至 2025-10-01
中文摘要
翻译
乳酸盐是一种重要的能量来源，被肌肉、心脏和脑组织利用。血乳酸在脓毒症或脓毒性休克患者中经常升高，其中高乳酸是死亡率的预测因素。然而，在COVID-19患者中，e
英文摘要
Lactate is an important energy source which is utilized by muscle, heart, and brain tissue. Blood lactate is frequently elevated in patients with sepsis or septic shock, where high lactate is predictive for mortality. In patients with COVID-19, however, e
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