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Establishing the chronic safety profile of focused ultrasound-mediated blood-spinal cord barrier opening in a large animal model

Establishing the chronic safety profile of focused ultrasound-mediated blood-spinal cord barrier opening in a large animal model
在大型动物模型中建立聚焦超声介导的血脊髓屏障开放的长期安全性概况
批准号：
477260
负责人：
O'Reilly Meaghan
金额：
$7.29万
依托单位：
Sunnybrook Research Institute (Toronto, Ontario)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
已结题
起止时间：
2022-10-01 至 2023-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=477260&lang=en
关键词：
Blood-Spinal Cord Barrier Focused Ultrasound Magnetic Resonance Imaging Microbubbles

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英文摘要
A key challenge in treating spinal cord disorders is that drug therapies do not reach the affected tissue in high enough concentrations due to the blood-spinal cord barrier (BSCB), which is the name to describe of a number of features of the blood vessels
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Establishing the chronic safety profile of focused ultrasound-mediated blood-spinal cord barrier opening in a large animal model.
Mechanisms of focused ultRasound mEdiated BrAin cLeAniNg Coupled with enhanced mEchanosensation (REBALANCE)
Canada Research Chair - Tier 2
  • 批准号：
    404316
  • 项目类别：
  • 资助金额：
    $43.71万
  • 财政年份：
    2018
  • 负责人：
    O'Reilly Meaghan
  • 依托单位：
    University of Toronto
Ultrasound-Mediated Drug Delivery to the Spinal Cord
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