Increasing the natural coagulability of transfusable platelets using mRNA-lipid nanoparticles

使用 mRNA-脂质纳米粒子提高可输注血小板的自然凝固性

• 批准号: 476039
• 负责人: Strong Colton
• 金额: $ 7.65万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-11-01 至 2025-11-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=476039&lang=en
• 关键词: Cell Therapy; Hemostasis And Thrombosis; Lipid Nanoparticles; Nanomedicine; Nucleic Acid Delivery; Platelet Activation; Platelet Engineering; Platelet Transfusion; Transfection; Trauma

Failure to control bleeding after injury, such as during trauma, childbirth and surgery, accounts for more than half of all operating room deaths. Platelets are blood cells that recognize and stick to sites of active bleeding, where they release specific

受伤后未能控制出血，如在创伤，分娩和手术期间，占所有手术室死亡人数的一半以上。血小板是识别并粘附在活动性出血部位的血细胞，在那里它们释放特定的