Determining the long-term outcomes and optimal treatment of childhood nephrotic syndrome using population-based administrative health data, target trial emulation, and a pilot adaptive clinical trial of a precision medicine treatment strategy

使用基于人群的管理健康数据、目标试验模拟和精准医学治疗策略的试点适应性临床试验来确定儿童肾病综合征的长期结果和最佳治疗

• 批准号: 475537
• 负责人: Robinson Cal
• 金额: $ 7.65万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-11-01 至 2025-11-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=475537&lang=en
• 关键词: Adaptive Clinical Trial; Administrative Healthcare Database; Bayesian; Pilot Study; Prospective Cohort Study; Target Trial Emulation

Nephrotic syndrome is one of the most common childhood kidney diseases. It affects up to 3,000 Canadian children each year. In nephrotic syndrome, the kidneys leak protein into the urine, which causes the body to swell. This causes breathing problems, inf

肾病综合征是最常见的儿童肾脏疾病之一。每年有多达3,000名加拿大儿童受到影响。在肾病综合症中，肾脏将蛋白质泄漏到尿液中，导致身体肿胀。这会导致呼吸问题，inf