Defining how chronic oxidative stress drives the evolution of aggressive breast cancers

定义慢性氧化应激如何驱动侵袭性乳腺癌的演变

• 批准号: 476209
• 负责人: Mirabelli Caitlynn N
• 金额: $ 7.65万
• 依托单位: Lady Davis Institute for Medical Research (Mtl)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-11-01 至 2025-11-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=476209&lang=en
• 关键词: Breast Cancer; Cellular Plasticity; Crispr Cas9; Flow Cytometry; Hypoxia; Mouse Biology; Oxidative Stress; Stress Response; Tumour Evolution; Tumour Microenvironment

Breast cancer is the most prevalent cancer in Canadian women and the second leading cause of cancer-related death in females. Despite significant progress in therapeutic development, aggressive tumours remain tolerant and unresponsive, resulting in ineffe

乳腺癌是加拿大妇女中最常见的癌症，也是女性癌症相关死亡的第二大原因。尽管在治疗发展方面取得了重大进展，但侵袭性肿瘤仍然耐受和无反应，导致无效治疗。