Isoform-specific Roles of Prolyl-Hydroxylases in the Regulation of ß-cell Insulin Secretion during a High-Fat Diet in Males

脯氨酰羟化酶在男性高脂肪饮食期间调节α细胞胰岛素分泌中的异构体特异性作用

• 批准号: 486408
• 负责人: Jentz Emelien
• 金额: $ 1.27万
• 依托单位: University of Waterloo (Ontario)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486408&lang=en
• 关键词: Alpha-Ketoglutarate; Anaplerosis; Cell Metabolism; High-Fat Diet; Hypoxia-Inducible Factors; Insulin Secretion; Islet Biology; Obesity; Pancreatic ß-Cell; Prolyl-Hydroxylase

Beta-cells in the pancreas release insulin to lower nutrient levels after a meal. Individuals with type 2 diabetes have non-functioning beta-cells. Without insulin, unregulated nutrient levels cause harmful problems. Western diets and obesity have made ty

胰腺中的β细胞在餐后释放胰岛素以降低营养水平。2型糖尿病患者的β细胞功能不全。没有胰岛素，不受调节的营养水平会导致有害的问题。西方饮食和肥胖使泰