Essential Role of ß3 PSI Domain in Integrin Receptor Assembly, Expression & Function

α3 PSI 结构域在整合素受体组装、表达中的重要作用

• 批准号: 486335
• 负责人: Hoard Brock K
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486335&lang=en
• 关键词: Alphaiib Betaiii; Hemostasis; Integrin; Platelets; Psi Domain; Thiol Isomerase Activity; Thrombosis

Cardiovascular diseases such as heart attack and stroke are the leading causes of morbidity and mortality worldwide. While current antithrombotic therapies have reduced mortality, serious adverse side effects remain for patients. Platelets are small, anuc

心脏病发作和中风等心血管疾病是全世界发病率和死亡率的主要原因。虽然目前的抗血栓治疗已经降低了死亡率，但对患者来说仍然存在严重的副作用。血小板很小，很小