A Loss of Intrinsic Biophysical and Transcriptomic Heterogeneity Accompanies Epileptogenesis in Hippocampal CA1 Neurons

海马 CA1 神经元癫痫发生伴随着内在生物物理和转录组异质性的丧失

• 批准号: 486485
• 负责人: Falby Madeleine R
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486485&lang=en
• 关键词: Electrophysiology; Epilepsy; Heterogeneity; Kainic Acid; Neuroscience; Rodent Models; Seizures; Single-Cell Rna Sequencing; Transcriptomics; Whole-Cell Patch Clamp Recording

Epilepsy is considered the most common serious neurological disorder in the world, impacting 50 million people worldwide and around 300,000 Canadians. It is a chronic condition involving seizures which are likened to an “electrical storm” in the brain, re

癫痫被认为是世界上最常见的严重神经系统疾病，影响全球5000万人和大约30万加拿大人。这是一种慢性疾病，涉及癫痫发作，被比作大脑中的“电风暴”，