L2M NSERC - Fibre-optic label-free single protein analysis for more efficient drug discovery assays

L2M NSERC - 光纤无标记单蛋白分析，可实现更高效的药物发现分析

• 批准号: 580665-2023
• 负责人: Gordon, ReuvenR
• 金额: $ 1.46万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=751825
• 关键词: L2M; NSERC; Fibre; optic; label

We are proposing perform market research/development for a product to measure single molecule protein interactions. The device will consist of an optical unit (light source, optical components, electrical components) as a one-off sale, and a consumable part (a nano-patterned optical fibre) that will come into physical contact with the end user's samples. The device would be utilised in the early stages of the drug discovery pipeline by researchers in pharmaceutical labs. It can provide fast (a few hours) information on protein binding. This method provides a result more quickly than current assays, it can be performed on smaller sample sizes (which saves time and cost in scale-up of sample) and does not require any labelling or special chemistry to prepare the samples (another time and cost saving).

我们建议对测量单分子蛋白质相互作用的产品进行市场研究/开发。该设备将包括一个一次性销售的光学单元（光源、光学组件、电气组件）和一个将与最终用户的样品物理接触的消耗部件（纳米图案光纤）。 该设备将在药物发现管道的早期阶段由制药实验室的研究人员使用。它可以提供快速（几个小时）的蛋白质结合信息。这种方法比目前的测定法更快地提供结果，它可以在更小的样品量上进行（这节省了样品放大的时间和成本），并且不需要任何标记或特殊化学来制备样品（另一种时间和成本节省）。