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Granzyme B mediates degradation of dermal-epidermal junction proteins in Stevens-Johnson syndrome and toxic epidermal necrolysis

Granzyme B mediates degradation of dermal-epidermal junction proteins in Stevens-Johnson syndrome and toxic epidermal necrolysis
颗粒酶 B 介导 Stevens-Johnson 综合征和中毒性表皮坏死松解症中真皮-表皮连接蛋白的降解
批准号：
486290
负责人：
Lane Michael M
金额：
$1.27万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2022
资助国家：
加拿大
项目状态：
已结题
起止时间：
2022-12-01 至 2023-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486290&lang=en
关键词：
Autoimmune Blistering Cutaneous Dermal-Epidermal Junction Drug Reaction Epidermal Necrolysis Granzyme B Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Wound Healing

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英文摘要
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious diseases that involve peeling and blistering of the skin. SJS is on the less serious side while TEN has worse outcomes. While these diseases are rare, those afflicted by them
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