The sex-different neuropharmacological effects of ketamine on the rostral linear nucleus: a potential mechanism for treatment of depression

氯胺酮对头端线性核的性别差异神经药理学作用：治疗抑郁症的潜在机制

• 批准号: 486083
• 负责人: Principe Anthony
• 金额: $ 1.27万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486083&lang=en
• 关键词: Depression; Fluorescent Retrobeads; Ketamine; Mechanism Of Action; Neurocircuitry; Neuron Mapping; Neurotransmitter Phenotype; Rostral Linear Nucelus; Sex Differences; Ventral Tegmental Area

Ketamine has shown significant promise as a treatment strategy in depression due to its rapid and strong antidepressant effects, yet the mechanisms underlying these effects, and sex-specific responses, are still being characterized. Our early evidence ind

氯胺酮已显示出显着的承诺作为抑郁症的治疗策略，由于其快速和强大的抗抑郁作用，但这些作用的机制，和性别特异性反应，仍在表征。我们的早期证据显示