Applications of Pullulan Nanostructures for Drug Delivery

普鲁兰多糖纳米结构在药物输送中的应用

• 批准号: 573019-2022
• 负责人: Demarquette, NicoleNR
• 金额: $ 2.99万
• 依托单位: École de technologie supérieure
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=754288
• 关键词: Applications; Pullulan; Nanostructures; Drug; Delivery

The main objective of this partnership between the Departments of Biotechnology (Professor Julio Santos), Chemical Engineering (Professor Amilton M. Santos) of the University of São Paulo, Brazil, , Mechanical Engineering of Ecole de Technologie Supérieure de Montréal, ÉTS (Professor Nicole Demarquette) and the Centre de Recherche du Centre Hospitalier de l'Université de Montréal and also ÉTS (Professor Sophie Lerouge) is to develop biomedical applications of Pullulan, a microbial biopolymer. The project will involve two professors from Brazil and two professors from Canada. It will also involve 2 Ph.D. and one M. Eng students. Furthermore, a Master student and one undergraduate student (scientific initiation) working in the laboratory of Pr. dos Santos will be also working on the project.The project will entail the development of three applications:- Application 1: Pullulan will be evaluated for its potential to encapsulate drugs employed in fighting acute viral lung diseases. Micro or nanospheres of pullulan which could be used in a spray for inhalation purposes will be produced. - Application 2: Pullulan, in the form of nonwoven membranes, will be evaluated with regards to its potential for encapsulation of drugs for the treatment of burns.- Application 3: Pullulan will be used to obtain hydrogels and further 3D printed (bioprinted).This project will enable activities in the biomedical field using new biotechnological technologies and natural resources.

生物技术系（Julio桑托斯教授）、化学工程系（Amilton M.巴西圣保罗大学的桑托斯（Santos）、蒙特利尔高等技术学院机械工程系、蒙特利尔大学中心医院研究中心（Centre de Recherche du Centre Hospitalier de l 'Université de Montréal）和ÉTS（Sophie Lerouge教授）正在开发普鲁兰多糖（一种微生物生物聚合物）的生物医学应用。该项目将有来自巴西的两名教授和来自加拿大的两名教授参加。它还将涉及2个博士学位。一个M。英语学生。此外，在桑托斯教授实验室工作的一名硕士生和一名本科生（科学启蒙）也将致力于该项目。该项目将涉及三个应用的开发：-应用1：普鲁兰多糖将被评估其封装用于对抗急性病毒性肺病的药物的潜力。将生产可用于吸入目的的喷雾剂中的普鲁兰多糖的微球或纳米球。- 应用二：以非织造膜的形式存在的普鲁兰多糖将被评估其用于治疗烧伤的药物封装的潜力。应用三：普鲁兰多糖将被用于获得水凝胶和进一步的3D打印（生物打印）。该项目将利用新的生物技术和自然资源在生物医学领域开展活动。