Applications of Pullulan Nanostructures for Drug Delivery

巴西圣保罗大学（SÃ）生物技术系（Julio Santos教授）、化学工程系（milton M. Santos教授）、蒙特萨伊理工大学机械工程系（ÉTS） （Nicole Demarquette教授）、蒙特萨伊理工大学医院中心研究中心和ÉTS （Sophie Lerouge教授）之间的这种伙伴关系的主要目标是开发微生物生物聚合物Pullulan的生物医学应用。该项目将包括两名来自巴西的教授和两名来自加拿大的教授。该项目还将涉及2名博士和1名硕士学生。此外，在dr . dos Santos实验室工作的一名硕士生和一名本科生（科学入门）也将参与该项目。该项目将需要开发三种应用：-应用1：将评估pululan封装用于治疗急性病毒性肺病的药物的潜力。制备可用于雾化吸入的普鲁兰微球或纳米球。-应用2：普鲁兰，以非织造膜的形式，将评估其用于烧伤治疗药物包封的潜力。-应用3：普鲁兰将用于获得水凝胶和进一步的3D打印（生物打印）。该项目将使生物医学领域的活动能够利用新的生物技术和自然资源。

The main objective of this partnership between the Departments of Biotechnology (Professor Julio Santos), Chemical Engineering (Professor Amilton M. Santos) of the University of São Paulo, Brazil, , Mechanical Engineering of Ecole de Technologie Supérieure de Montréal, ÉTS (Professor Nicole Demarquette) and the Centre de Recherche du Centre Hospitalier de l'Université de Montréal and also ÉTS (Professor Sophie Lerouge) is to develop biomedical applications of Pullulan, a microbial biopolymer. The project will involve two professors from Brazil and two professors from Canada. It will also involve 2 Ph.D. and one M. Eng students. Furthermore, a Master student and one undergraduate student (scientific initiation) working in the laboratory of Pr. dos Santos will be also working on the project.The project will entail the development of three applications:- Application 1: Pullulan will be evaluated for its potential to encapsulate drugs employed in fighting acute viral lung diseases. Micro or nanospheres of pullulan which could be used in a spray for inhalation purposes will be produced. - Application 2: Pullulan, in the form of nonwoven membranes, will be evaluated with regards to its potential for encapsulation of drugs for the treatment of burns.- Application 3: Pullulan will be used to obtain hydrogels and further 3D printed (bioprinted).This project will enable activities in the biomedical field using new biotechnological technologies and natural resources.