Investigating the neural basis of impaired sensory learning with mesoscale 2-photon microscopy in mouse models of Huntington’s disease

使用中尺度 2 光子显微镜研究亨廷顿病小鼠模型感觉学习受损的神经基础

• 批准号: 486259
• 负责人: Trappenberg Kai Y
• 金额: $ 1.27万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486259&lang=en
• 关键词: 2 Photon Mesoscale Imaging; Behaviourally Relevant Neurophysiology; Calcium Dynamics; Cortical Brain Circuitry And Rewiring; Huntington'S Disease; Mental Dysfunction Intervention; Neuronal Networks And Organization; Sensory Discrimination; Sensory Learnin

Huntington’s disease (HD) is genetic brain disorder characterized by progressive movement and cognitive difficulties, including learning. Most studies focus on motor learning, but new findings in mice show abnormal brain activity associated with sensory s

亨廷顿氏病（HD）是一种以进行性运动和包括学习在内的认知困难为特征的遗传性脑部疾病。大多数研究都集中在运动学习上，但在老鼠身上的新发现表明，大脑异常活动与感觉系统有关