Canada 150 Research Chair in Mathematical Biology & Medicine

加拿大 150 数学生物学研究主席

• 批准号: C150-2017-00010
• 负责人: Layton, AnitaTam
• 金额: $ 25.5万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Canada 150 Research Chairs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=755586
• 关键词: Canada; 150; Research; Chair; Mathematical

Dr. Layton is a pioneer in demonstrating the use of mathematics as the new microscope in biology and medicine. Her modelling work was instrumental in solving one of the longest-standing mysteries in traditional physiology: How does the mammalian kidney produce urine that is much more concentrated than blood plasma? More recently, she has done ground-breaking translational work that focuses on the efficacy of therapeutic treatments for hypertension and diabetes. Key contributions include revealing (1) the molecular mechanisms underlying the different responses to hypertensive treatments among men and women, and (2) potential side effects of a new "miracle drug" for diabetes.

莱顿博士是将数学作为生物学和医学的新显微镜的先驱。她的建模工作有助于解决传统生理学中一个长期存在的谜团：哺乳动物肾脏是如何产生比血浆浓度高得多的尿液的？最近，她做了开创性的转化工作，专注于高血压和糖尿病的治疗效果。主要贡献包括揭示(1)男性和女性对高血压治疗不同反应的分子机制，以及(2)一种治疗糖尿病的新“灵丹妙药”的潜在副作用。