Use of a RHAMM peptide mimetic, NP-110, to reduce fibrosis in a novel rat model of radiation-induced capsular contracture

使用 RHAMM 肽模拟物 NP-110 减少辐射诱发的包膜挛缩的新型大鼠模型中的纤维化

• 批准号: 485949
• 负责人: Minkhorst Kathryn
• 金额: $ 1.27万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=485949&lang=en
• 关键词: Breast Reconstruction; Capsular Contracture; Fibrosis; Implant; Radiation; Rodent Model

Capsular contracture is a common but unpredictable complication of breast implant surgery, particularly following radiotherapy, which can be particularly devastating in the setting of post-mastectomy breast reconstruction. Capsular contracture is consider

包囊挛缩是乳房植入手术的常见但不可预测的并发症，特别是在放疗后，这在乳房切除术后乳房重建的情况下可能特别具有破坏性。包囊挛缩被认为是