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Impact of host responses on mpox pathogenesis and tecovirimat efficacy in the Collaborative Cross mouse model of genetic diversity

Impact of host responses on mpox pathogenesis and tecovirimat efficacy in the Collaborative Cross mouse model of genetic diversity
遗传多样性协作交叉小鼠模型中宿主反应对 MPOX 发病机制和 tecovirimat 功效的影响
批准号：
481136
负责人：
Rasmussen Angela
金额：
$36.43万
依托单位：
University of Saskatchewan
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-02-01 至 2025-02-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=481136&lang=en
关键词：
Gender And Health Genetics Infection And Immunity

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英文摘要
The host response to infection is a critical determinant of disease severity. However, host responses that dictate the outcome of mpox (monkeypox) virus disease are largely unknown. Furthermore, although antiviral therapies can effectively treat mpox infe
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Journal of Genetics and Genomics