Signaling complexes of N-type calcium channels and opioid receptor family members: implications for opioid analgesia and tolerance

N型钙通道和阿片受体家族成员的信号复合物：对阿片类镇痛和耐受的影响

• 批准号: 477639
• 负责人: Zamponi Gerald W
• 金额: $ 70.78万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-03-01 至 2028-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=477639&lang=en
• 关键词: Calcium Channels; Gpcr; Morphine; N-Type; Opioid Receptor; Optogenetics; Pain

Chronic pain can be a debilitating condition for which there are currently few treatment options, leading to a major burden on our Health care system and a ~$60 Billion loss annually to the Canadian economy due to lost productivity. Pain signals travel a

慢性疼痛可能是一种使人虚弱的疾病，目前几乎没有治疗选择，这会给我们的医疗保健系统带来重大负担，并因生产力下降而每年给加拿大经济造成约600亿美元的损失。疼痛信号传递到