Development and Update of Quantitative Pharmacology Concepts and Computational Models for a Better Understanding of Drug Fate and Action
定量药理学概念和计算模型的发展和更新,以更好地了解药物的命运和作用
基本信息
- 批准号:RGPIN-2020-05982
- 负责人:
- 金额:$ 1.75万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2022
- 资助国家:加拿大
- 起止时间:2022-01-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This research program bases on solid theoretical foundations to provide mathematical methodologies that help gaining better insights into the underlying mechanisms of the biological system, its transition between healthy and pathological conditions, and its action on/reaction with exogenous compounds. It addresses highly topical issues that became very important with the increasing role that mathematics play in the drug research area. It focuses on the development of advanced quantitative methodologies that are part of an integrative approach combining systems pharmacology with pharmacometrics (quantitative pharmacology). In fact, empirical culture, which historically prevailed in this field, is gradually fading to give more ground to these complementary or even alternative mathematical and computational tools, with the aim to rationalize and quantify drug development and use. Quantification of the complex relationship that exists between the drug, the patient biology and his drug behaviour is at the core of our interest. Whenever possible, concrete computational tools, nourished by the research components, are developed and bring an added value for the return on investment of public funds. This research program is fully dedicated to train a whole new generation of quantitative pharmacological scientists. It consists in three main lines, concerned with the development of integrative mathematical models, update of the most used pharmacokinetic metrics and the proposition of rational pharmacological strategies and minimally invasive approaches in a context of limited sampling, using physiological and pharmacokinetic modeling with mathematical analysis.
该研究计划基于坚实的理论基础,提供数学方法,有助于更好地了解生物系统的潜在机制,健康和病理条件之间的过渡,以及其对外源性化合物的作用/反应。随着数学在药物研究领域的作用越来越大,它解决了变得非常重要的高度热门的问题。它侧重于开发先进的定量方法,这些方法是将系统药理学与药物计量学(定量药理学)相结合的综合方法的一部分。事实上,历史上在这一领域占主导地位的经验文化正在逐渐消失,为这些补充甚至替代的数学和计算工具提供更多的基础,目的是合理化和量化药物开发和使用。量化药物、患者生物学及其药物行为之间存在的复杂关系是我们感兴趣的核心。在可能的情况下,开发了由研究部分提供营养的具体计算工具,为公共资金的投资回报带来了附加值。该研究计划完全致力于培养全新一代的定量药理学科学家。它包括三条主线,涉及综合数学模型的发展,最常用的药代动力学指标的更新和合理的药理学策略和微创方法在有限的采样背景下,使用生理和药代动力学建模与数学分析的建议。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Nekka, Fahima其他文献
Trapezoid bioequivalence: A rational bioavailability evaluation approach on account of the pharmaceutical-driven balance of population average and variability.
- DOI:
10.1002/psp4.12775 - 发表时间:
2022-04 - 期刊:
- 影响因子:3.5
- 作者:
Soufsaf, Sara;Nekka, Fahima;Li, Jun - 通讯作者:
Li, Jun
Dynamical systems analysis as an additional tool to inform treatment outcomes: The case study of a quantitative systems pharmacology model of immuno-oncology
- DOI:
10.1063/5.0022238 - 发表时间:
2021-02-01 - 期刊:
- 影响因子:2.9
- 作者:
Balti, Aymen;Zugaj, Didier;Nekka, Fahima - 通讯作者:
Nekka, Fahima
An Evaluation Approach for the Performance of Dosing Regimens in Attention-Deficit/Hyperactivity Disorder Treatment
注意力缺陷/多动症治疗中给药方案效果的评估方法
- DOI:
10.1089/cap.2016.0108 - 发表时间:
2017-05-01 - 期刊:
- 影响因子:1.9
- 作者:
Bonnefois, Guillaume;Robaey, Philippe;Nekka, Fahima - 通讯作者:
Nekka, Fahima
A Bayesian approach for the estimation of patient compliance based on the last sampling information
- DOI:
10.1007/s10928-011-9196-2 - 发表时间:
2011-06-01 - 期刊:
- 影响因子:2.5
- 作者:
Barriere, Olivier;Li, Jun;Nekka, Fahima - 通讯作者:
Nekka, Fahima
Impact of sampling time deviations on the prediction of the area under the curve using regression limited sampling strategies
- DOI:
10.1002/bdd.1951 - 发表时间:
2015-10-01 - 期刊:
- 影响因子:2.1
- 作者:
Sarem, Sarem;Nekka, Fahima;Li, Jun - 通讯作者:
Li, Jun
Nekka, Fahima的其他文献
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{{ truncateString('Nekka, Fahima', 18)}}的其他基金
Development and Update of Quantitative Pharmacology Concepts and Computational Models for a Better Understanding of Drug Fate and Action
定量药理学概念和计算模型的发展和更新,以更好地了解药物的命运和作用
- 批准号:
RGPAS-2020-00098 - 财政年份:2022
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Development and Update of Quantitative Pharmacology Concepts and Computational Models for a Better Understanding of Drug Fate and Action
定量药理学概念和计算模型的发展和更新,以更好地了解药物的命运和作用
- 批准号:
RGPIN-2020-05982 - 财政年份:2021
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Development and Update of Quantitative Pharmacology Concepts and Computational Models for a Better Understanding of Drug Fate and Action
定量药理学概念和计算模型的发展和更新,以更好地了解药物的命运和作用
- 批准号:
RGPAS-2020-00098 - 财政年份:2021
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Development and Update of Quantitative Pharmacology Concepts and Computational Models for a Better Understanding of Drug Fate and Action
定量药理学概念和计算模型的发展和更新,以更好地了解药物的命运和作用
- 批准号:
RGPAS-2020-00098 - 财政年份:2020
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Collaborative Research Program in Pharmacometrics and Quantitative Systems Pharmacology
药理学和定量系统药理学合作研究项目
- 批准号:
539271-2019 - 财政年份:2020
- 资助金额:
$ 1.75万 - 项目类别:
Collaborative Research and Development Grants
Development and Update of Quantitative Pharmacology Concepts and Computational Models for a Better Understanding of Drug Fate and Action
定量药理学概念和计算模型的发展和更新,以更好地了解药物的命运和作用
- 批准号:
RGPIN-2020-05982 - 财政年份:2020
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Collaborative Research Program in Pharmacometrics and Quantitative Systems Pharmacology
药理学和定量系统药理学合作研究项目
- 批准号:
539271-2019 - 财政年份:2019
- 资助金额:
$ 1.75万 - 项目类别:
Collaborative Research and Development Grants
Rethinking and Formulating Integrative Methodologies for a Better Understanding of Quantitative Drug-Related Issues
重新思考和制定综合方法以更好地理解定量药物相关问题
- 批准号:
RGPIN-2015-03955 - 财政年份:2019
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Rethinking and Formulating Integrative Methodologies for a Better Understanding of Quantitative Drug-Related Issues
重新思考和制定综合方法以更好地理解定量药物相关问题
- 批准号:
RGPIN-2015-03955 - 财政年份:2018
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Rethinking and Formulating Integrative Methodologies for a Better Understanding of Quantitative Drug-Related Issues
重新思考和制定综合方法以更好地理解定量药物相关问题
- 批准号:
RGPIN-2015-03955 - 财政年份:2017
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
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