Using a Dual Nanopore Device to Characterize DNA Nanotubes and Nunchucks

在本联盟催化剂提案中，我们将与Fygenson集团（物理部，位于美国加利福尼亚州圣巴巴拉的加州大学）将我们的双纳米孔技术与他们通过DNA纳米技术生产的DNA纳米管相结合。 双孔技术将有助于表征DNA管; DNA管反过来将有助于阐明纳米孔物理学并增强双孔技术的应用。 这项工作将加强加拿大在纳米技术、医疗诊断和基因组学等联邦创新优先领域的存在。 Fygenson教授是一个理想的合作者，因为她的团队在通过自组装设计新型DNA纳米管结构（例如“DNA Nunchuck”）方面的专业知识以及她在结构聚合物力学方面的专业知识。 HQP培训将通过我们团队之间的双周虚拟会议以及HQP对我们各自实验室的为期一个月的合作访问进行;这些访问将增强HQP的沟通，协作和领导技能。 EDI将通过包容性招聘、性别平衡的领导团队（由参与EDI的两名PI组成）以及强调在关键专业技能方面密切指导不同HQP的培训计划来促进。

In this Alliance Catalyst proposal we will establish a collaboration with the Fygenson group (Phys. Dept., Univ. California at Santa Barbara, CA, USA) to interface our dual nanopore technology with their DNA nanotubes produced via DNA nanotechnology. The dual-pore technology will assist in characterizing the DNA tubes; the DNA tubes will in turn help elucidate nanopore physics and enhance application of dual-pore technology. This work will enhance Canada's presence in Federal Innovation priority areas such as nanotechnology, medical diagnostics and genomics. Prof. Fygenson is an ideal collaborator due to her group's expertise in designing novel DNA nanotube constructs via self-assembly (e.g. "DNA Nunchuck") and her expertise in the polymer mechanics of the constructs. HQP training will be carried out via bi-weekly virtual meetings between our groups and month-long collaboration visits of HQP to our respective labs; these visits will enhance HQP communication, collaboration and leadership skills. EDI will be fostered via inclusive hiring, a gender-balanced leadership team with both PIs engaged in EDI, and a training plan emphasizing close mentorship of diverse HQP in key professional skills.