Using a Dual Nanopore Device to Characterize DNA Nanotubes and Nunchucks

使用双纳米孔装置表征 DNA 纳米管和双节棍

• 批准号: 578525-2022
• 负责人: Reisner, WalterWW
• 金额: $ 1.82万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=762345
• 关键词: Using; Dual; Nanopore; Device; Characterize

In this Alliance Catalyst proposal we will establish a collaboration with the Fygenson group (Phys. Dept., Univ. California at Santa Barbara, CA, USA) to interface our dual nanopore technology with their DNA nanotubes produced via DNA nanotechnology. The dual-pore technology will assist in characterizing the DNA tubes; the DNA tubes will in turn help elucidate nanopore physics and enhance application of dual-pore technology. This work will enhance Canada's presence in Federal Innovation priority areas such as nanotechnology, medical diagnostics and genomics. Prof. Fygenson is an ideal collaborator due to her group's expertise in designing novel DNA nanotube constructs via self-assembly (e.g. "DNA Nunchuck") and her expertise in the polymer mechanics of the constructs. HQP training will be carried out via bi-weekly virtual meetings between our groups and month-long collaboration visits of HQP to our respective labs; these visits will enhance HQP communication, collaboration and leadership skills. EDI will be fostered via inclusive hiring, a gender-balanced leadership team with both PIs engaged in EDI, and a training plan emphasizing close mentorship of diverse HQP in key professional skills.

在该 Alliance Catalyst 提案中，我们将与 Fygenson 小组（美国加利福尼亚州圣巴巴拉市加利福尼亚大学物理系）建立合作关系，将我们的双纳米孔技术与他们通过 DNA 纳米技术生产的 DNA 纳米管结合起来。 双孔技术将有助于表征 DNA 管； DNA 管反过来将有助于阐明纳米孔物理并增强双孔技术的应用。 这项工作将增强加拿大在纳米技术、医疗诊断和基因组学等联邦创新优先领域的影响力。 Fygenson 教授是一个理想的合作者，因为她的团队在通过自组装设计新型 DNA 纳米管结构（例如“DNA Nunchuck”）方面拥有专业知识，并且她在结构的聚合物力学方面拥有专业知识。 总部培训将通过我们各小组之间每两周一次的虚拟会议以及总部对我们各自实验室为期一个月的合作访问进行；这些访问将增强总部的沟通、协作和领导技能。 EDI 将通过包容性招聘、性别平衡的领导团队（两名 PI 均参与 EDI）以及强调对不同 HQP 在关键专业技能方面进行密切指导的培训计划来促进。