ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN

青春期:塑造成人社交大脑的敏感时期

基本信息

  • 批准号:
    RGPIN-2022-05266
  • 负责人:
  • 金额:
    $ 5.68万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2022
  • 资助国家:
    加拿大
  • 起止时间:
    2022-01-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

The importance of environmental experiences in the early years of life in shaping brain development and function is well known. In comparison, there has been little focus on the adolescent period, a period in which there is ongoing brain development, and a time of life that is different from adulthood in terms of social behaviour and many aspects of physiology. My research has shown in rats that social relationships in adolescence shape social behaviour in adulthood, using a manipulation of social experiences (social instability) that seems to have no lasting effect on behaviour when experienced in adulthood. In this grant, we propose to investigate the neural underpinnings of the social instability-induced changes in social behaviour of adolescents. Objective 1 addresses the lack of normative data on social development in females and how sensitivity to reward develops across adolescence in both sexes. Objective 2 investigates the mechanisms for the effects of adolescent social instability on social behaviour in both sexes, focussing on the role of neuropeptides, glucocorticoid, hormones, and endocannabinoid signalling. Objective 3 investigates normative changes in the regulation of the hypothalamic-pituitary-adrenal axis by the hypothalamic-pituitary-gonadal axis during adolescence, and the role of such changes for social development. The experiments of my research program are important steps in addressing gaps in our knowledge of the adolescent period of life, which will contribute to the understanding the developmental mechanisms and social experiences that build the social brain. Further, the research program will provide excellent research training and transferrable skills for undergrad and graduate students.
众所周知,早年的环境经历在塑造大脑发育和功能方面的重要性。相比之下,很少关注青少年时期,这是一个大脑持续发育的时期,在社会行为和生理学的许多方面与成年期不同。我在老鼠身上的研究表明,青春期的社会关系会影响成年后的社会行为,这种社会关系对社会经历(社会不稳定性)的操纵似乎对成年后的行为没有持久的影响。在这个补助金,我们建议调查的神经基础的社会不稳定引起的变化,在青少年的社会行为。目标1解决了缺乏关于女性社会发展的规范性数据,以及两性在青春期对奖励的敏感性如何发展。目的2研究青少年社会不稳定对两性社会行为的影响机制,重点关注神经肽、糖皮质激素、激素和内源性大麻素信号的作用。目的3探讨青春期下丘脑-垂体-性腺轴对下丘脑-垂体-肾上腺轴调节的规范性变化,以及这种变化对社会发展的作用。我的研究项目的实验是解决我们对青少年时期的知识差距的重要步骤,这将有助于理解建立社会大脑的发展机制和社会经验。此外,研究计划将为本科生和研究生提供优秀的研究培训和可转移的技能。

项目成果

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McCormick, Cheryl其他文献

McCormick, Cheryl的其他文献

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{{ truncateString('McCormick, Cheryl', 18)}}的其他基金

ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    RGPIN-2016-03714
  • 财政年份:
    2021
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Individual
Molecular Tools for Behavioural Neuroscience Research
行为神经科学研究的分子工具
  • 批准号:
    RTI-2022-00216
  • 财政年份:
    2021
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Research Tools and Instruments
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    RGPIN-2016-03714
  • 财政年份:
    2020
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Individual
Equipment to investigate social brain development in adolescence in rats.
研究大鼠青春期社会性大脑发育的设备。
  • 批准号:
    RTI-2019-00034
  • 财政年份:
    2018
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Research Tools and Instruments
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    492900-2016
  • 财政年份:
    2018
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    RGPIN-2016-03714
  • 财政年份:
    2018
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Individual
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    RGPIN-2016-03714
  • 财政年份:
    2017
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Individual
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    492900-2016
  • 财政年份:
    2017
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    RGPIN-2016-03714
  • 财政年份:
    2016
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Individual
The lasting influence of social stressors in adolescence on development
青春期社会压力源对发展的持久影响
  • 批准号:
    288348-2009
  • 财政年份:
    2015
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Individual

相似海外基金

ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    RGPIN-2016-03714
  • 财政年份:
    2021
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Individual
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    RGPIN-2016-03714
  • 财政年份:
    2020
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Individual
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    RGPIN-2016-03714
  • 财政年份:
    2019
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Individual
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    492900-2016
  • 财政年份:
    2019
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    492900-2016
  • 财政年份:
    2018
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    RGPIN-2016-03714
  • 财政年份:
    2018
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Individual
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    RGPIN-2016-03714
  • 财政年份:
    2017
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Individual
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    492900-2016
  • 财政年份:
    2017
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
ADOLESCENCE: A SENSITIVE PERIOD FOR SHAPING THE ADULT SOCIAL BRAIN
青春期:塑造成人社交大脑的敏感时期
  • 批准号:
    RGPIN-2016-03714
  • 财政年份:
    2016
  • 资助金额:
    $ 5.68万
  • 项目类别:
    Discovery Grants Program - Individual
Adolescence: A Sensitive Period for Nicotine Addiction
青春期:尼古丁成瘾的敏感期
  • 批准号:
    6878932
  • 财政年份:
    2004
  • 资助金额:
    $ 5.68万
  • 项目类别:
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