Renal Tubule-Specific NRF2 Deletion Down-Regulates SGLT2 and Angiotensinogen Expression and Ameliorates GFR and Kidney Injury in Akita Mice
Renal Tubule-Specific NRF2 Deletion Down-Regulates SGLT2 and Angiotensinogen Expression and Ameliorates GFR and Kidney Injury in Akita Mice
批准号:
495599
负责人:
Su Ke
金额:
$0.09万
依托单位国家:
加拿大
项目类别:
财政年份:
2023
资助国家:
加拿大
项目状态:
已结题
起止时间:
2023-09-01 至 2024-09-01
中文摘要
该研究旨在研究NRF2(一种与糖尿病相关的蛋白质)在糖尿病肾病(DKD)进展中的作用。研究人员在秋田小鼠(t的一种模型)身上检测了从肾小管中特异性去除NRF2的效果
英文摘要
The study aimed to investigate the role of NRF2, a protein associated with diabetes, in the progression of diabetic kidney disease (DKD). The researchers examined the effects of removing NRF2 specifically from the renal tubules in Akita mice, a model of t
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