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Defining the molecular assembly mechanism of bacterial amyloid from single protein molecules to mature fibrils

Defining the molecular assembly mechanism of bacterial amyloid from single protein molecules to mature fibrils
定义细菌淀粉样蛋白从单个蛋白质分子到成熟原纤维的分子组装机制
批准号：
494840
负责人：
Dee Derek R
金额：
$7.29万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
已结题
起止时间：
2023-09-01 至 2024-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=494840&lang=en
关键词：
Amyloid Fibrils Bioconjugate Chemistry Biofilm Biophysics Cryoem Force Spectroscopy Optical Tweezers Protein Aggregation Protein Folding Single Molecule Methods

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英文摘要
Many bacteria can form a dense matrix known as biofilm that helps them attach to surfaces and offers protection, aiding their survival. A key structural component of biofilm are amyloid fibrils, protein aggregates comprised of thousands of protein molecul
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