Role of USP7 and Potential Therapy in Human Cancers.

USP7 的作用和在人类癌症中的潜在疗法。

• 批准号: 494924
• 负责人: Leng Roger P
• 金额: $ 7.29万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-09-01 至 2024-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=494924&lang=en
• 关键词: Breast Cancer; Deubiquitination; Oncogene; P53; Protein Stability; Ube4b; Ubiquitination; Usp7

The importance of tumor suppressor p53 in the prevention of cancer is highlighted by the fact that p53 is inactivated in more than 50% of all human tumors. Regulation of p53 expression and stability is essential for maintaining normal cell growth. p53 is

肿瘤抑制因子p53在预防癌症中的重要性通过以下事实突出：在所有人类肿瘤中超过50%的p53被失活。p53表达和稳定性的调节对于维持细胞正常生长至关重要。p53是