Investigation of leptin resistance in mouse models of childhood-onset morbid obesity.

儿童期病态肥胖小鼠模型瘦素抵抗的研究。

• 批准号: 200366
• 负责人: Devos Julia J
• 金额: $ 1.27万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-02-01 至 2011-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=200366&lang=en
• 关键词: Hypothalamus; Leptin; Leptin Resistance; Magel2; Mouse Models; Neurons; Obesity; Prader-Willi Syndrome

Leptin is a hormone produced by fat tissue. Leptin tells the brain whether our body has all the fat it needs. Any changes to the leptin sensor (receptor) or to the brain cells that sense leptin, can change this energy balance. In some cases of childhood

瘦素是一种由脂肪组织产生的激素。瘦素告诉大脑我们的身体是否有它所需要的所有脂肪。 瘦素传感器（受体）或感知瘦素的脑细胞的任何变化都可以改变这种能量平衡。 在某些儿童时期