Studies on the defective protein anabolism in human lung cancer: role of insulin resistance, acute-phase response, and gluconeogenesis.

人类肺癌中蛋白质合成代谢缺陷的研究：胰岛素抵抗、急性期反应和糖异生的作用。

• 批准号: 200357
• 负责人: Macadams Jacqueline M
• 金额: $ 1.27万
• 依托单位: Macdonald Campus of McGill Univ. (Ste-Anne-de-Bell)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-02-01 至 2011-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=200357&lang=en
• 关键词: Acute Phase Protein Synthesis; Amino Acid Contribution To Gluconeogenesis; Effect Of Insulin Resistance On Glucose Metabolism; Effect Of Insulin Resistance On Protein Metabolism; Euglycemic; Hyperinsulinemic; Isoaminoacidemic Clamp Study; Metabolic Effect

Protein loss, mostly from muscle, is very common in the advanced stages of lung cancer and this affects the patients' physical function, response to treatment and quality of life. We propose that cancer patients are losing muscle proteins because they ar

蛋白质损失（主要来自肌肉）在肺癌晚期非常常见，这会影响患者的身体功能、对治疗的反应和生活质量。 我们认为癌症患者正在失去肌肉蛋白，因为他们