基于脑机交互的多模态神经反馈促进PTSD康复的机制及应用研究

创伤后应激障碍(PTSD)的神经康复很重要，神经反馈(NF)能促进PTSD康复，但其作用机制依然不清晰，证据不足。现有单模态NF干预PTSD的效果和接受度有限。为此，本课题另辟蹊径，首次引入变革性的脑机交互(BCI)，提出一种新的基于BCI的多模态NF促进PTSD康复方法。PTSD涉及深层或浅层多个脑区结构及功能的异常，目前主要采用单模态NF逆转这些异常，然而单模态方法受空间或时间分辨率的限制。因而，本课题拟采用同步fMRI-EEG和同步EEG-fNIRS NF，设计随机双盲对照试验，深入研究NF促进PTSD康复的机制，并利用BCI的哥白尼革命来监测PTSD患者大脑的动态变化，为PTSD康复提供客观的评价指标。最后，基于揭示的多模态NF促进PTSD康复的机制、新证据以及脑成像特征，构建便携式EEG-fNIRS NF促进PTSD康复的原型系统，可望用于促进PTSD的康复。

Neurological rehabilitation of patients with post-traumatic stress disorder (PTSD) is very important. Neurofeedback (NF) can promote PTSD recovery. However, its mechanism of action is still unclear and insufficient evidence. Traditional or existing single-mode NF interventions in PTSD has limited effect and acceptance. To this end, this project develops a new way, the revolutionary brain-computer interface (BCI) technology was introduced, and proposed a new BCI-based multimodal NF to promote PTSD rehabilitation to further reveal the mechanism of NF intervention in PTSD rehabilitation and provide new evidence. PTSD may involve abnormalities in the structure and brain function of multiple deep or shallow brain regions. Traditional NF methods mainly use single-mode NF to reverse these abnormalities. However, single-mode methods are limited by their respective spatial or temporal resolution and other limitations. Therefore, this project intends to use synchronous EEG-fMRI NF and synchronous EEG-fNIRS NF to design a randomized double-blind controlled experiment to deeply study the mechanism of NF promoting PTSD rehabilitation, and use BCIs Copernicus revolution to monitor the dynamic changes of the brain of PTSD patients , calculate brain imaging features, and provide additional objective evaluation indicators for PTSD rehabilitation. Finally, based on the mechanism of multimodal NF promoting PTSD rehabilitation revealed above, new evidence and brain imaging characteristics, it is planned to construct a portable EEG-fNIRS-NF prototype system for promoting PTSD rehabilitation, which may be used to promote the rehabilitation of PTSD patients.