非酒精性脂肪肝炎（NASH）作为日益高发的慢性肝病，发病机制极为复杂。目前尚无疗效确切的药物，而运动是改善NASH的最有效方式。我们前期人群研究发现，中等强度的运动即可显著降低肝内甘油三酯蓄积，同时上调血清中IL-6的水平。动物实验发现，运动显著上调肌肉和血清中的IL-6水平，并对高脂饮食诱导的肝内脂质蓄积和炎症浸润发挥显著改善作用，在IL-6基因敲除后，运动的改善作用显著下降。由于脂质蓄积和炎症反应是NASH的重要组成元素，我们推测IL-6可介导运动对NASH的改善作用，拟开展以下研究：1. 运动通过IL-6对肝内脂质代谢和炎症反应的调控作用；2. 肝实质细胞内IL-6R/STAT3信号通路对运动改善NASH的作用及机制；3. 肝内巨噬细胞中IL-6R/STAT3信号通路对运动改善NASH的作用及机制。通过这些研究的阐释，为临床预防及治疗NASH提供新的思路和策略。

Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease, the pathogenesis of NASH is complicated. There is no effective drug, and exercise is the most effective therapy to improve NASH. Our previous clinical study found that moderate intensity exercise significantly reduced the accumulation of triglyceride in the liver and increased the level of IL-6 in serum. Animal experiments found that exercise significantly increased muscle and serum levels of IL-6, and reduced the lipid accumulation and inflammation in the liver induced by high-fat diet. However, these effects of exercise were abundantly diminished in the IL-6 knockout mice. As the lipid accumulation and inflammation are important components of NASH, we supposed that IL-6 mediated the effect of exercise on the improvement of NASH, and designed the following researches: 1. The effect of exercise on the regulation of lipid metabolism and inflammation in the liver via IL-6; 2. The role and mechanism of IL-6R /STAT3 signaling pathway in hepatocytes to improve NASH; 3. The role and mechanism of IL-6R /STAT3 signaling pathway in liver macrophages to improve NASH. This project may provide more effective strategies in the treatment of NASH.