具有良好抗凝血性的人造器官和矫形植入体在人类疾病防治中的重要性越来越明显，其研究与发展将对人类健康与和谐具有重要的现实意义。然而，此类医用金属材料普遍存在血液相容性较差，面临离子渗出和表面凝血等严重问题。如何理解弄清血液与材料表界面之间的相互作用，是提高和优化抗凝血性从而实现其应用价值的关键。本项目基于固-液界面相互作用本质上是由界面能和界面系统润湿状态决定的事实，提出从液体(水、血液)与固体表面润湿行为的角度，深入探索常用血管支架材料（医用不锈钢316L、317L）表面上氧化锌纳米薄膜的抗凝血性。首先，实现抗凝血氧化锌纳米孔、阵列或量子点的可控生长；其次，分析血液在薄膜表面的动态和静态润湿行为；然后，利用血小板黏附实验和溶血实验评估其生物相容性；最后，结合分子动力学理论模拟，综合分析氧化锌薄膜的抗凝血机理及其主要影响因素，为进一步优化设计性能优良的抗凝血性材料提供一定的理论和实验依据。

The anrificial organs and orthopedic implants with excellent antithrombogenicity have received more and more attention, and their research and development will be significant for the health and harmony. However, when these materials are applied, ion seepage and surface thrombosis may occur. How to understand and clarify the correlation between the surface structures and biocompatibility is the key to improve the anticoaguation. This proposal will focus on the study of surface modification of ZnO nanofilms grown on general scaffolds for vascular tissue (such as 316L and 317L) and investigate the anticoaguation of superhydrophilic or superhydrophobic ZnO films. Firstly, the controllable growth of ZnO nanopore, nanoarrays, and quantum dots will be investigated, and the surface wettability and stability of various droplets with different size on ZnO surface will be analyzed. Secondly, the surface wetting behaviors of the blood will be measured based on the surface wettability of ZnO films. Thirdly, the hemocompatibility will be analyzed by means of hemolysis test and platelet ahhesion experiments. Finally, combining with the molecular dynamics simulation, the anticoaguation mechanisms of ZnO films as well as their influencing factors will be analyzed. These results will provide valuable scientific basis for the optimum design of the related materials with excellent anticoaguation in future.