近年来，针对茂基三价金属钴、铑、铱催化的C(sp2)-H活化方法学研究发展迅猛，特别是与极性多重键的偶联反应中都表现出明显且独特的优越性，但是针对C(sp3)-H键官能团化的研究报道却仅有数例。在本项目中，我们将深入展开茂基三价金属钴、铑、铱催化的C(sp3)-H键活化的方法学研究及其应用的推广，进一步提高其底物和反应类型的多样性，希望发现一系列新颖、高效、环境友好的合成方法学，并尽可能结合机理实验以及密度泛函理论(DFT)计算，提出并证明相关的催化反应机理。总之，本研究项目具有明显原创性和探索性，具有较强的理论意义和应用潜力。

Group 9 [Cp*Co(III), Cp*Rh(III), and Cp*Ir(III)] complexes catalyzed functionalizations of C(sp2)-H bonds have in recent years attracted significant interest. In sharp contrast to C(sp2)-H bonds, the selective functionalization of C(sp3)-H bonds is much more challenging and only very limited examples have been reported. In this project, we will carry out a comprehensive investigation into the Cp*Co(III)-, Cp*Rh(III)-, and Cp*Ir(III)-catalyzed C(sp3)-H functionalizations with a variety of coupling partners, thus largely improving the diversity of substrates and reaction types. At the same time, mechanistic experiments and DFT calculations will also be carried out to gain insights into the reaction mechanism. In summary, this original and novel research has great potential in many applications.