新型两亲性含氟丙烯酰胺单体及其均聚物的精确合成及其19F核磁共振成像性能的研究

含氟聚合物因其优异的尺寸可控性、结构功能多样性被广泛用于构筑19F核磁共振(MRI)造影剂，在重大疾病的诊疗领域具有巨大的应用潜力。为了获得高的核磁成像性能，造影剂材料需要含有高的氟含量。但是高氟含量的含氟聚合物往往会在水溶液中发生聚集，进而造成核磁信号衰减、成像灵敏度降低。如何保证高氟含量的含氟聚合物具有良好的水溶性是获得高成像灵敏性19F造影的关键。为此，本项目拟通过构筑两亲性含氟丙烯酰胺单体，以亚砜基团作为亲水基团，合成三种含有六氟异丙基和全氟叔丁基的高氟含量丙烯酰胺单体, 结合活性聚合的策略，制备具有良好水溶性的高氟含量丙烯酰胺均聚物，并探索其作为19F造影剂材料的应用潜景。并通过单体中亲疏水基团的比例对聚合物水溶液行为、体外成像性能的影响，进一步加深我们对于含氟聚合物构效关系的认识和理解。

Fluoropolymers are widely used in 19F nuclear magnetic resonance (MRI) contrast agents (CAs) with the ease of tailoring their size and the diversity of structure, which exhibit tremendous potential in the diagnosis and treatment of human diseases. To achieve high-resolution MRI images, a high density of 19F nuclei is required in this field. However, owing to the inherent hydrophobicity of fluorinated moieties, it often appears that the aggregation of fluorine-containing fragments in an aqueous solution, resulting in attenuated MRI signal and low sensitivity. Therefore, It is crucial for high imaging sensitivity 19F contrast agents to balance the high fluorine content and good water solubility. In this work, we intend to build amphiphilic fluoroacrylamide monomers, based on synthesizing three high fluorine acrylamide monomers containing hexafluoroisopropyl, perfluorotertbutyl as fluorine fragments, and sulfoxide group as a hydrophilic fragment. With the strategy of living polymerization, acrylamide homopolymer with well water solubility and high fluorine content will be prepared. And the potential of the above-mentioned polymers as 19F contrast will be preliminarily explored. It will also be studies that The effects of the proportion of hydrophilic and hydrophobic groups in the monomer on the behavior of polymer aqueous solution and in vitro imaging. This work can further deepen our understanding of the structure-activity relationship of functional fluoropolymers.