氮掺杂介孔碳负载PdM双金属催化剂制备及其催化氢解有机苄胺衍生物反应研究

针对现有活性炭负载钯催化剂在有机苄胺衍生物氢解反应中催化活性低、易失活问题，通过改进载体孔结构、增加固定位和引入具有协同作用的第二金属如Ni，Cu，Fe等方法，构建新型氮掺杂介孔碳负载PdM双金属催化剂。拟通过介孔结构设计，促进活性金属高分散，提升反应物传输效率，有望大幅度提高催化氢解活性；通过掺杂氮和引入第二金属，实现抑制活性金属表面迁移与团聚目标，最终希望达到新型催化剂在有机苄胺衍生物氢解反应中高活性且长寿命（循环使用）的设计目标。同时拟开展反应机理、底物普适性等有机苄胺衍生物催化氢解反应方法学研究，着重探索该催化剂在某典型有机苄胺类化合物的氢解反应应用。本项目将设计、研制新固体催化剂与经典有机化学反应研究相结合，所形成的新催化反应方法，对该交叉领域的科学研究及学科发展具有重要意义，其方法上的突破有望满足国家重大战略需求；相关基础研究成果有望为医药和化工中间体合成提供一种高效新方法。

The current activated carbon supported Pd catalyst shows low catalytic activity for hydrogenation of organic benzylamine derivatives and instability. In order to solve the problems, this project is aimed to design a new kind of PdM bimetallic catalyst using nitrogen doped mesoporous carbon support through improving the pore structure of support, increasing the fixed site and introducing the second metal, such as Ni, Cu and Fe. First of all, on the base of the modified pore structure, the dispersity of active metal can be enhanced and the mass transfer rate of the reactants can be increased, and hence the catalytic hydrogenation performance of the organic benzylamine derivatives will be significantly improved. Meanwhile, the introduction of the N and second metal could inhibit surface motion and aggregation of the active metal, which considerably prolongs the lifetime of the new catalyst and maintains its high activity. Then the methodology of organic benzylamine derivatives for catalytic hydrogenation, including reaction mechanism and substrate universality, will be studied in order to explore the application of the new catalyst in a typical catalytic hydrogenation reaction of organic benzylamine compound. This project combines the design and development of new catalyst with the classic organic chemical reaction together to discover the new catalytic methodology, which is meaningful for the development of this interdisciplinary area. The establishment of the new method meets the national demand of science development and proposes a new way to synthesis intermediate in medical industry and chemical industry.