“苗族打药”马桑狗帮的抗炎药效物质及机制研究

苗药“马桑狗帮”为虎耳草科落新妇属植物大落新妇Astilbe grandis的根。苗医药调研发现，“苗族打药”马桑狗帮在贵州黔东南苗族地区治疗跌打损伤，腰腿痛、筋骨疼痛、关节炎和风湿病等有显著疗效，由于其在抗炎方面疗效突出而引入三甲医院使用。前期我们已通过抗炎的动物实验验证了其安全性和有效性。但目前对其同属植物的抗炎方面的研究只停留在提取物的初步活性研究中，对该苗药Astilbe grandis的研究更未见报道，其中的抗炎有效部位及活性成分还不明确，作用机制尚未阐明。因此，本项目拟寻找该苗药的活性部位、药效物质及对其进行体内外抗炎活性和机制的研究。这不仅能为研发具有我国自主知识产权的抗炎新药寻找新的活性先导化合物，而且也有利于促进该苗药更深入的开发利用。

Astilbe grandis, which belongs to the Astilbe genus of the family Saxiffagaceae, is well-known in Miao Nationality Areas of Guizhou Province under the name “Ma Sang Gou Bang”. The investigation of the Miao nationality medicine in Guizhou reveals that “Ma Sang Gou Bang” traditionally known as “Da Yao” has been used for treating bruises,back pain, aching pain and rheumatism in Miao Nationality Areas of Southeast Guizhou. The safety and effectiveness of “Ma Sang Gou Bang” is verified by our previous animal experiment. However, the study of the anti-inflammatory on this genus was seldom reported and its active constituents and action mechanism were remains unclear. This study is focus on the drug action locus, active components and action mechanism of “Ma Sang Gou Bang”, which provide valuable information for founding the analgesic and anti-inflammatory lead compounds and development and utilization of this Ethnic Medicine.